Term |
Definition |
Allele |
An allele is defined (in the TCP world) as a genetic
mutation to a particular gene or chromosome. A mouseline can
have one or multiple alleles (such as in the case of
multi-transgenics) and thus alleles can be shared between lines.
Alleles are characterized by MGI and are often found on the MGI
database. |
Allele Confidentiality |
refers to the ability of more than the
creator of the allele to be able to see a mouseline on LIMS.
Alleles that are published and are listed on MGI are
automatically not confidential and are searchable by anyone with
LIMS access. This promotes sharing of mice within the facility.
If you generate a novel allele then you have the option of
keeping it confidential for the purposes of your experiments. If
you combine this novel allele with ones not confidential you can
maintain confidentiality by keeping the box checked. |
Mouseline |
A mouseline is a strain of mouse with alleles
associated with it (or not, in the case of WTs). Thus the ROSA
rtTA allele can be on both a B6 and CD-1 background, thus
creating two distinct mouselines. |
Mouseline Passport |
is essentially an identity card for
the mouseline. It lists the alleles, the background, and the
contact information of a particular line. |